Extrahepatic Replication Sites of Hepatitis E Virus (HEV)

Hepatitis E virus (HEV) is an emerging viral disease known to cause acute hepatitis globally. Various genotypes of HEV have been identified that produce genotype specific lesions depending on the targeted population. Pregnant or immunosuppressed individuals develop significantly more severe in comparison general In last 40 years, we discovered tropism not restricted liver, and replication was demonstrated multiple organs. Out 10 body systems described humans, produces causing a broad range extrahepatic clinical manifestations each them. Affected include nervous musculoskeletal, cardiovascular, digestive, endocrine, integumentary, renal, respiratory, immune, reproductive producing systemic lesions. All signs are caused by either direct these tissues, indirectly various immune mediated mechanisms. Extrahepatic features allowed it cross placental barrier, blood–brain barrier (BBB), blood–testis (BTB) do typically grant entry viruses general. Thus, this review, summarized sites HEV, listed where invaded, animal models including immunocompetent were used study HEV.